Loading...

PE anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
M170_PE_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_CD11b_Antibody_IHC_031413
    Fixed whole mount mouse spleen was stained with Alexa Fluor® 488 F4/80 (red) (clone BM8), Brilliant Violet 421™ CD3ε (green) (clone 145-2C11), and PE CD11b (blue) (clone M1/70). Isotype controls at the same concentrations were used for the negative control. Cells were mounted in Prolong Gold and imaged with a Leica SP8 confocal. Image courtesy of Grzegorz Chodaczek and Zbigniew Mikulski at LIAI.
Compare all formats See PE spectral data See more IHC data...
Cat # Size Price Quantity Check Availability Save
101207 50 µg 45€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
101208 200 µg 139€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
IHC - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Additional Product Notes

View more applications data for this product in our Scientific Poster Library.

Application References
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Chida J, et al. 2020. PLoS Pathog. 16:e1008823. PubMed
  2. Guo Y, et al. 2021. Exp Ther Med. 353:21. PubMed
  3. Grigsby SM, et al. 2021. Cancers (Basel). 13:. PubMed
  4. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  5. Yates AG, et al. 2021. J Neuroinflammation. 18:15. PubMed
  6. Witherel CE, et al. 2021. Biomaterials. 269:120667. PubMed
  7. DeBuque RJ, et al. 2022. Dev Dyn. 251:988. PubMed
  8. He D, et al. 2022. Immunity. 55:159. PubMed
  9. Koenig A, et al. 2022. Front Immunol. 12:791100. PubMed
  10. Shang SQ, et al. 2022. Neoplasma. 69:755. PubMed
  11. Tan YY, et al. 2022. Bio Protoc. 12:e4307. PubMed
  12. Wemlinger SM, et al. 2022. J Immunol. 208:1566. PubMed
  13. Li Y, et al. 2022. J Exp Clin Cancer Res. 41:128. PubMed
  14. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  15. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  16. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  17. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  18. Albayrak E, et al. 2022. J Cell Biochem. 123:2009. PubMed
  19. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  20. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  21. McNamara NB, et al. 2023. Nature. 613:120. PubMed
  22. Sundarasivarao PYK, et al. 2022. Front Immunol. 13:1011944. PubMed
  23. Morrow RJ, et al. 2022. Cells. 11: . PubMed
  24. Ullah I, et al. 2023. Cell Rep Med. 4:100893. PubMed
  25. Pavliuchenko N, et al. 2023. Front Immunol. 13:1035226. PubMed
  26. Marritt KL, et al. 2023. Front Immunol. 13:1087991. PubMed
  27. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  28. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  29. Wang L, et al. 2023. Oxid Med Cell Longev. 2023:6480848. PubMed
  30. Citro A, et al. 2023. Nat Commun. 14:878. PubMed
  31. Kodali S, et al. 2022. J Immunol. 208:1085. PubMed
  32. Tang Y, et al. 2022. Dev Cell. 57:480. PubMed
  33. Marsh SE, et al. 2022. Nat Neurosci. 25:306. PubMed
  34. Ajay AK, et al. 2022. Cell Rep. 38:110473. PubMed
  35. Friedman D, et al. 2022. J Immunol. 208:1845. PubMed
  36. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  37. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  38. Sauter M, et al. 2022. STAR Protoc. 3:101664. PubMed
  39. Glorieux C, et al. 2022. J Adv Res. 40:109. PubMed
  40. Krasniewski LK, et al. 2022. Elife. 11:. PubMed
  41. Wu Q, et al. 2023. Front Immunol. 13:1081719. PubMed
  42. Suzuki Y, et al. 2023. Front Immunol. 14:1089905. PubMed
  43. Zhang L, et al. 2023. Commun Biol. 6:211. PubMed
  44. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  45. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  46. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  47. Mascarau R, et al. 2023. J Cell Biol. 222:. PubMed
  48. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  49. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  50. Petenkova A, et al. 2023. Nat Commun. 14:2761. PubMed
  51. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  52. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  53. Li M, et al. 2023. BMC Cancer. 23:497. PubMed
  54. Zhao C, et al. 2023. NPJ Regen Med. 8:29. PubMed
  55. Kisielow J, et al. 2019. Nat Immunol. 1.286111111. PubMed
  56. Li A, et al. 2020. Oncol Lett. 1.899305556. PubMed
  57. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  58. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  59. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  60. Nigam S, et al. 2020. Mol Imaging Biol. 22:685. PubMed
  61. Hu K, et al. 2022. J Extracell Vesicles. 11:e12199. PubMed
  62. Ho YH, et al. 2019. Cell Stem Cell. 25:407. PubMed
  63. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  64. Lei G, et al. 2016. Antimicrob Agents Chemother. 60: 1289 - 1297. PubMed
  65. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  66. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  67. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  68. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  69. Yan F, et al. 2022. Cancer Discov. 12:792. PubMed
  70. Lee S, et al. 2021. JCI Insight. 6:. PubMed
  71. Zhao X, et al. 2022. Front Mol Biosci. 9:786864. PubMed
  72. Deng Y, et al. 2021. Acta Pharmacol Sin. 42:149. PubMed
  73. Pan J, et al. 2021. Mol Ther Nucleic Acids. 26:970. PubMed
  74. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  75. Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed
  76. Abels ER et al. 2019. Cell Rep. 28(12):3105-3119 . PubMed
  77. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  78. Prajeeth C,et al. 2017. J Neuroinflammation.. 10.1186/s12974-017-0978-3. PubMed
  79. Zhang Y, et al. 2020. Oncol Lett. 1.053472222. PubMed
  80. Dumas SJ, et al. 2021. STAR Protocols. 2(3):100523. PubMed
  81. Zhang Z, et al. 2020. J Immunol. 204:3400. PubMed
  82. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  83. Xiao X, et al. 2020. J Hematol Oncol. 0.597222222. PubMed
  84. Elkabets M, et al. 2009. J Immunol. 182:4874. PubMed
  85. Sauter M, et al. 2022. iScience. 25:103677. PubMed
  86. Conforti A, et al. 2021. PLoS One. 16:e0259894. PubMed
  87. Götz P, et al. 2022. Int J Mol Sci. 23:. PubMed
  88. Adachi Y, et al. 2022. Nat Commun. 13:5117. PubMed
  89. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  90. Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
  91. Forte E, et al. 2020. J Cell Mol Med. . PubMed
  92. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  93. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  94. Forte D, et al. 2020. Cell Metab. 32:829. PubMed
  95. Coppo M, et al. 2016. Nat Commun. 7:12254. PubMed
  96. Wang X, et al. 2016. PLoS Pathog. 12: 1005367. PubMed
  97. Hiraishi Y, et al. 2018. Sci Rep. 8:18052. PubMed
  98. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  99. Shears RK, et al. 2020. J Allergy Clin Immunol. 145:1272. PubMed
  100. Chen X, et al. 2021. Cell Death Differ. 28:1237. PubMed
  101. Stolp B, et al. 2022. Cell Rep. 38:110387. PubMed
  102. Craver BM, et al. 2020. Blood Adv. 4:312. PubMed
  103. Llewellyn GN, et al. 2018. J Neurovirol. 24:192. PubMed
  104. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  105. Kalucka J, et al. 2020. Cell. 764:180. PubMed
  106. Joseph R, et al. 2021. Br J Cancer. 125:176. PubMed
  107. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  108. Price J, et al. 2015. Diabetes. 64: 3521 - 3531. PubMed
  109. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  110. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  111. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  112. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  113. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  114. Chen F, et al. 2022. Evid Based Complement Alternat Med. 2022:1240242. PubMed
  115. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  116. Turkowski K, et al. 2017. Glia. 10.1002/glia.23234. PubMed
  117. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  118. Hengyou Weng et al. 2018. Cell stem cell. 22(2):191-205 . PubMed
  119. Nakagawa S et al. 2017. Cell host & microbe. 22(5):667-677 . PubMed
  120. Swidergall M, et al. 2019. Cell Rep. 28:423. PubMed
  121. Ganeshan K et al. 2019. Cell. 177(2):399-413 . PubMed
  122. Trenevska I, et al. 2021. PLoS One. 16:e0249967. PubMed
  123. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  124. Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed
  125. Haugh KA, et al. 2021. eLife. 0.416666666666667. PubMed
  126. Perner C, et al. 2020. Immunity. 53(5):1063-1077.e7. PubMed
  127. Endo Y, et al. 2020. FASEB J. 34:16086. PubMed
  128. Diao N, et al. 2016. Sci Rep. 6:34672. PubMed
  129. Huang L, et al. 2016. J Biol Chem. 291: 6232 - 6244. PubMed
  130. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  131. Pan J, et al. 2020. J Neuroinflammation. 17:97. PubMed
  132. Li K, et al. 2022. J Immunother Cancer. 10:. PubMed
  133. Hongu T, et al. 2022. Nat Cancer. 3:486. PubMed
  134. Rogawski DS, et al. 2021. Nat Commun. 12:2792. PubMed
  135. Paraiso HC, et al. 2018. J Neuroinflammation. 0.694444444. PubMed
  136. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  137. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  138. Hammond TR, et al. 2019. Immunity. 50:253. PubMed
  139. Wang C, et al. 2017. J Immunol. 10.4049/jimmunol.1700671. PubMed
  140. Donley DW, et al. 2021. PLOS ONE. 16(5):e0250606. PubMed
  141. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  142. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  143. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  144. Xiao Z, et al. 2015. Cancer Lett. 360:302. PubMed
  145. Nakaya M, et al. 2017. J Clin Invest. 127:383. PubMed
  146. Mayo L, et al. 2008. J Immunol. 181:92. PubMed
  147. Zheng Y, et al. 2022. Front Pharmacol. 12:816032. PubMed
  148. Dane EL, et al. 2022. Nat Mater. 21:710. PubMed
  149. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  150. Zhang X, et al. 2022. Cells. 11:. PubMed
  151. An J,et al. 2017. Sci Rep.. 10.1038/s41598-017-13629-0. PubMed
  152. Wang L, et al. 2017. Front Immunol.. 10.3389/fimmu.2017.01754. PubMed
  153. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  154. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  155. Zhang S, et al. 2019. Mol Med Rep. 19:5377. PubMed
  156. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  157. Riffelmacher T et al. 2017. Immunity. 47(3):466-480 . PubMed
  158. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  159. Jin R, et al. 2020. Mol Cancer Ther. . PubMed
  160. Nguyen TKT, et al. 2020. Am J Pathol. 286:190. PubMed
  161. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  162. Pang D, et al. 2015. Clin Transl Immunology. 4: e41. PubMed
  163. Bertino P, et al. 2019. Oncoimmunology. 8:1601482. PubMed
  164. Keshavarz M, et al. 2020. Virol J. 17:64. PubMed
  165. He L, et al. 2019. iScience. 0.790972222. PubMed
  166. Kotaki R, et al. 2020. Sci Rep. 10:13554. PubMed
  167. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  168. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  169. Deng Z, et al. 2017. Oncogene. 36:639. PubMed
  170. Liu D et al. 2019. Immunity. 51(1):64-76 . PubMed
  171. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  172. Souza COS, et al. 2021. iScience. 24(6):102548. PubMed
  173. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  174. Hildebrand KM, et al. 2021. PLoS One. 16:e0253864. PubMed
  175. Jaworska K, et al. 2015. J Immunol. 194:325. PubMed
  176. Chen Y, et al. 2015. PLoS One. 10: 0135217. PubMed
  177. Li L, et al. 2015. J Am Soc Nephrol. 26: 2183-2197. PubMed
  178. Hou M, et al. 2020. Stem Cell Res Ther. 11:55. PubMed
  179. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  180. Malekghasemi S, et al. 2020. Cell Biol Int. 44:2031. PubMed
  181. Hönes J, et al. 2017. Sci Rep. . 10.1038/s41598-017-15866-9. PubMed
  182. Niemann J, et al. 2019. Nat Commun. 10:3236. PubMed
  183. Han D, et al. 2021. J Immunol Res. 6688053:2021. PubMed
  184. Nguyen GT, et al. 2021. iScience. 24(8):102871. PubMed
  185. Garg M, et al. 2021. Cell Reports. 34(6):108736. PubMed
  186. Cao DY, et al. 2020. J Biol Chem. 295:1369. PubMed
  187. Moorlag SJCFM, et al. 2020. Cell Rep. 33:108387. PubMed
  188. Koshida R, et al. 2015. Biochem Biophys Res Commun. 463: 109-115. PubMed
  189. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  190. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  191. Baik JE, et al. 2022. Clin Transl Med. 12:e758. PubMed
  192. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  193. Di Martino L, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:901. PubMed
  194. Zhang C, et al. 2022. Nat Commun. 13:3468. PubMed
  195. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  196. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  197. Luong-Gardiol N, et al. 2019. Cancer Cell. 35:649. PubMed
  198. Murray C, et al. 2018. Lab Chip. 18:2396. PubMed
  199. Mizuno T, et al. 2017. Sci Rep. 7:42714. PubMed
  200. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  201. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  202. Kan X, et al. 2015. Cardiovasc Res. 10.1093/cvr/cvv255. PubMed
  203. Colombo M, et al. 2022. iScience. 25:105042. PubMed
  204. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  205. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  206. Jorapur A, et al. 2022. PLoS Pathog. 18:e1010200. PubMed
  207. Yang Y, et al. 2022. Elife. 11:. PubMed
  208. Bolkhovitina EL, et al. 2022. Int J Mol Sci. 23: . PubMed
  209. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  210. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  211. He J, et al. 2019. J Clin Invest. 130. PubMed
  212. Huang Y, et al. 2019. Cancer Cell. 35:677. PubMed
  213. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  214. Bermejo-Jambrina M, et al. 2021. EMBO J. 40:e106765. PubMed
  215. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  216. Koikawa K, et al. 2021. Cell. 184:4753. PubMed
  217. Sokol L, et al. 2021. STAR Protocols. 2(2):100489. PubMed
  218. Yamakawa D, et al. 2021. Cell Reports. 34(10):108817. PubMed
  219. Troutman TD, et al. 2021. STAR Protocols. 2(1):100363. PubMed
  220. Wang L, et al. 2012. PLoS One. 7:e40056. PubMed
  221. Staschke K, et al. 2009. J Immunol. 183:568. PubMed
  222. Challa TD, et al. 2020. Cell Reports. 30(10):3424-3433. PubMed
  223. Perez-Garcia CG, et al. 2022. Mol Ther Nucleic Acids. 28:87. PubMed
  224. Uslu M, et al. 2020. J Cell Physiol. 235:9644. PubMed
  225. Zhai K, et al. 2021. Nat Cancer. 2:1136. PubMed
  226. Chiang HY, et al. 2022. Nat Commun. 13:874. PubMed
  227. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  228. Minuesa G, et al. 2019. Nat Commun. 10:2691. PubMed
  229. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  230. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  231. Wang Q, et al. 2018. Int J Biol Sci. 14:147. PubMed
  232. Favuzzi E, et al. 2021. Cell. 184(15):4048-4063.e32. PubMed
  233. Langhauser F, et al. 2014. Stroke. 45:1799. PubMed
  234. Garcia-Bonilla L, et al. 2014. J Immunol. 193:2531. PubMed
  235. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  236. Tan S, et al. 2006. J Immunol. 176:2872. PubMed
  237. Roy AG, et al. 2021. Int J Mol Sci. 22:. PubMed
  238. Liu S, et al. 2022. J Neuroinflammation. 19:35. PubMed
  239. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  240. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  241. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  242. Babagana M, et al. 2021. Aging (Albany NY). 13:19207. PubMed
  243. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  244. Dungan CM, et al. 2022. Aging Cell. 21:e13528. PubMed
  245. Hsu Y, et al. 2017. Biochem Biophys Res Commun.. 10.1016/j.bbrc.2017.10.067. PubMed
  246. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  247. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  248. Gomez–Ospina N, et al. 2019. Nat Commun. 3.225694444. PubMed
  249. Calle P, et al. 2021. Cells. 10:. PubMed
  250. Li T, et al. 2021. J Neuroinflammation. 81:18. PubMed
  251. Guo M, et al. 2020. Brain. 1476:143. PubMed
  252. Houben T, et al. 2020. J Pathol. 251:429. PubMed
  253. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  254. Li L, et al. 2014. J Immunol. 192:1034. PubMed
  255. Demers M, et al. 2012. Proc Natl Acad Sci U S A. 109:13076. PubMed
  256. Gladow N, et al. 2020. PLoS One. 15:e0227734. PubMed
  257. Szeifert V, et al. 2021. Front Immunol. 12:671995. PubMed
  258. Saber M, et al. 2021. J Neurosci Res. 99:1136. PubMed
  259. Wang W, et al. 2021. J Am Heart Assoc. 10:e019142. PubMed
  260. Berghoff SA, et al. 2021. Nat Neurosci. 24:47. PubMed
  261. Cao W, et al. 2021. Int J Mol Sci. 22:. PubMed
  262. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  263. Li YT, et al. 2019. Elife. 8:e47642. PubMed
  264. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  265. Xiao G, et al. 2018. Cell. 173:470. PubMed
  266. Spangenberg E, et al. 2019. Nat Commun. 10:3758. PubMed
  267. Wu ZJ, et al. 2018. Int J Oncol. 52:1209. PubMed
  268. Yuan Y, et al. 2020. Front Physiol. 0.967361111. PubMed
  269. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  270. Toyohara T, et al. 2020. Cell Stem Cell. 27:147. PubMed
  271. Dong Y, et al. 2021. Commun Biol. 4:560. PubMed
  272. Scheiblich H, et al. 2021. Cell. 184:5089. PubMed
  273. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  274. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  275. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  276. Bennett FC, et al. 2018. Neuron. 98:1170. PubMed
  277. Zhang T, et al. 2018. PLoS One. 13:e0196571. PubMed
  278. Eisemann T, et al. 2019. Front Oncol. 9:187. PubMed
  279. Lin T, et al. 2021. PLoS Pathog. 17:e1009557. PubMed
  280. Casselli T, et al. 2021. PLoS Pathog. 17:e1009256. PubMed
  281. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  282. Lin KH, et al. 2020. Nat Genet. 52:408. PubMed
  283. Jablonski K, et al. 2015. PLoS One. 10: 0145342. PubMed
  284. Sanders K, et al. 2015. Cancer Immunol Res. 3: 891-901. PubMed
  285. Yuan C, et al. 2015. Biochem Biophys Res Commun. 464: 249-255. PubMed
  286. Resende M, et al. 2013. J Immunol. 191:262. PubMed
  287. Gerdes P, et al. 2022. Nat Commun. 13:7470. PubMed
  288. Düking T, et al. 2022. Sci Adv. 8:eabo7639. PubMed
  289. Muri J, et al. 2020. Cell Reports. 29(9):2731-2744.e4.. PubMed
  290. Liu Y, et al. 2019. Sci Rep. 9:18970. PubMed
  291. Wang X, et al. 2021. Cell. 184:5357. PubMed
  292. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  293. Xia D, et al. 2022. Mol Neurodegener. 17:41. PubMed
  294. Koide S, et al. 2022. iScience. 25:103603. PubMed
  295. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  296. Li K, et al. 2020. Nat Commun. 4.844444444. PubMed
  297. Avalle L, et al. 2020. Mol Ther Methods Clin Dev. 0.793055556. PubMed
  298. Zhou Q, et al. 2020. Nat Immunol. 1.393055556. PubMed
  299. Rodríguez L, et al. 2021. Biomolecules. 11: . PubMed
  300. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  301. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  302. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  303. Yang N, et al. 2022. Nat Commun. 13:2336. PubMed
  304. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  305. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  306. Nguyen GT, et al. 2020. eLife. 9:e56656.. PubMed
  307. Hoyer FF, et al. 2020. Immunity. 51(5):899-914.e7.. PubMed
  308. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  309. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  310. Saber M, et al. 2020. Eur J Neurosci. 52:2791. PubMed
  311. Garcia-Bonilla L, et al. 2015. J Neurosci. 35: 14783 - 14793. PubMed
  312. Baruch K, et al. 2015. EMBO J. 34: 1816 - 1828. PubMed
  313. Schmidt C, et al. 2005. J Immunol. 175:2286. PubMed
  314. Bozoglu T, et al. 2022. Adv Sci (Weinh). 9:e2103867. PubMed
  315. Shen H, et al. 2022. Nat Commun. 13:5013. PubMed
  316. Zhang X, et al. 2022. J Exp Clin Cancer Res. 41:246. PubMed
  317. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  318. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  319. Bahmani B, et al. 2021. Nat Commun. 12:1999. PubMed
  320. Fielding C, et al. 2022. Nat Commun. 13:543. PubMed
  321. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  322. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  323. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  324. Evavold CL, et al. 2021. Cell. 184(17):4495-4511.e19. PubMed
  325. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  326. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  327. Henkle TR, et al. 2021. Cancer Res. 81:4560. PubMed
  328. Hirako N, et al. 2014. PLoS One. 9:103282. PubMed
  329. Chen Z, et al. 2016. Innate Immunity. 22: 419 - 432. PubMed
  330. Wang T, et al. 2022. Int J Nanomedicine. 17:2191. PubMed
  331. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  332. Zhang M, et al. 2019. Autophagy. 1.423611111. PubMed
  333. Gawish R, et al. 2022. Elife. 11:. PubMed
  334. Wunderlich CM, et al. 2018. Nat Commun. 9:1646. PubMed
  335. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  336. Amend A, et al. 2021. Int J Mol Sci. 22:. PubMed
  337. Rana MN, et al. 2021. Front Pharmacol. 12:643215. PubMed
  338. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  339. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
  340. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  341. Scharenberg SG, et al. 2020. Nat Commun. 2.76875. PubMed
  342. K K, et al. 2016. Haematologica. 151159. PubMed
  343. Han J, et al. 2015. Cancer Res . 75: 5273 - 5282. PubMed
  344. Cai W, et al. 2019. J Neuroinflammation. 0.788194444. PubMed
  345. Fernando N, et al. 2020. Front Cell Dev Biol. 0.691666667. PubMed
  346. Saber M, et al. 2021. J Neurotrauma. 38:2862. PubMed
  347. Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
  348. Zhang SJ, et al. 2021. Adv Sci (Weinh). 8:2003410. PubMed
  349. Steinmetz TD, et al. 2021. Autophagy. 17:2238. PubMed
  350. Hohsfield LA, et al. 2021. Elife. 10:. PubMed
  351. Kaya-Tilki E, et al. 2021. PLoS One. 16:e0260633. PubMed
  352. Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed
  353. Dougan M, et al. 2018. Cancer Immunol Res. 6:389. PubMed
  354. Abdel Malik R, et al. 2017. Circ Res. 120:99. PubMed
RRID
AB_312790 (BioLegend Cat. No. 101207)
AB_312791 (BioLegend Cat. No. 101208)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD11b
Specificity Alt (DOES NOT SHOW ON TDS):
CD11b
App Abbreviation (DOES NOT SHOW ON TDS):
FC,IHC
Hidden Names (DOES NOT SHOW ON TDS):
aM integrin, alpha integrin, alphaM integrin, alpha M integrin, integrin alphaM, integrin aM, integrin alpha M, CD11, Macrophage, Myeloid Dendritic Cell, Neutrophil, NK Cell, Plasmacytoid Dendritic Cell, Microglia
UniProt
View information about CD11b on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Spark PLUS B550™ anti-mouse/human CD11b M1/70 FC
Go To Top Version: 2    Revision Date: 03-14-2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account