Login / Register 
United States ($) USD
Austria (€) EUR
Belgium (€) EUR
Finland (€) EUR
France (€) EUR
Germany (€) EUR
Ireland (€) EUR
Japan (¥) JPY
Luxembourg (€) EUR
Netherlands (€) EUR
Switzerland (CHF) CHF
United Kingdom (£) GBP
- Clone
- S22037G (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD158b1 (KIR2DL2, p58.2, NKAT6), CD158b2 (KIR2DL3, p58.3, NKAT2)
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with purified anti-human CD158b (KIR2DL2/KIR2DL3) (clone S22037G) (left) or purified mouse IgG2a, κ isotype control (right), followed by goat anti-mouse IgG PE. Cells were then stained with anti-human CD56 (clone QA17A16) APC.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 317508 | 100 µg | 288 CHF | ||||
CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.
CD158b1 and CD158b2 are 38 kD two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with ITIM motifs. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL2 and KIR2DL3 have been reported to bind to certain HLA-C antigens on a target cell (HLA-C*01, HLA-C*03, HLA-C*07, for example).
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human KIR2DL2 transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone S22037G can block the binding of clone DX27 on target cells.
Based on in-house testing on different KIR-expressing transfectants, clone S22037G does not interact with other KIR protein family members.
Antigen Details
- Structure
- 38 kD two Ig-like extracellular domain glycoprotein
- Distribution
-
Subset of NK cells, subset of T cells
- Function
- NK cell regulation
- Ligand/Receptor
- Some HLA-C molecules
- Cell Type
- Lymphocytes, NK cells, T cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
- Vilches C, et al. 2002. Annu Rev Immunol. 92.107361.
- Middleton D, et al. 2010. Immunol. 123:8.
- Moesta A.K, et al. 2012. Frontiers Immu. 3.336.
- Moradi S, et al. 2021. Nature Commu. 12.2173.
- Gene ID
- 3803 View all products for this Gene ID 3804 View all products for this Gene ID
- UniProt
- View information about CD158b on UniProt.org
Related FAQs
Other Formats
View All CD158b Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD158b (KIR2DL2/KIR2DL3) | S22037G | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human CD158b (KIR2DL2/KIR2DL3)
Human peripheral blood lymphocytes were stained with purifie...
Follow Us