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- Clone
- H8R23.Rec (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Capillary morphogenesis gene 2 (CMG2)
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood monocytes were stained with purified anti-human ANTXR2 (clone H8R23.Rec) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by goat anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 318405 | 100 µg | 430 CHF | ||||
ANTXR2, also known as anthrax toxin receptor 2, is a type I transmembrane protein with an extracellular von Willebrand factor A (vWA) domain, an immunoglobulin (Ig)-like domain, a single transmembrane helix and a cytoplasmic tail. It binds to the Bacillus anthracis toxin subunit, protective antigen (PA), in a divalent cation-dependent manner. Upon binding of PA, multiple toxin-receptor complexes assemble in lipid rafts, which are then internalized. This results in the formation of a pore in the endosomal membrane, enabling the escape of other anthrax toxin subunits into the cytoplasm. Additionally, ANTXR2 interacts with laminin, and possibly collagen type IV, suggesting a role for this receptor in capillary formation and basement membrane assembly.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
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Clone H8R23.Rec and completely block the binding of clone H8R23 on target cells.
Antigen Details
- Structure
- 54 kD, Type I transmembrane protein, van Willebrand factor A (vWA) domain, Ig-like domain
- Distribution
-
T cell, B cell, dendritic cell, monocytes, and granulocytes
- Function
- The ANTXR2 protein acts as a receptor for the toxin that causes anthrax, allowing the toxin to attach to cells and trigger disease. The ANTXR2 protein is also involved in the formation of capillaries and maintaining the structure of basement membranes.
- Ligand/Receptor
- Protective antigen (PA), laminin, collagen type IV
- Cell Type
- B cells, Dendritic cells, Granulocytes, Monocytes, T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- CD Molecules
- Antigen References
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- Burgi J, et al. 2017. Nature Comms. 8:15861.
- Scobie HM, et al. 2003. Proc Natl Acad Sci USA. 100:5170-4.
- Gene ID
- 118429 View all products for this Gene ID
- UniProt
- View information about ANTXR2 on UniProt.org
Related FAQs
Other Formats
View All ANTXR2 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human ANTXR2 Recombinant Antibody | H8R23.Rec | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human ANTXR2 Recombinant Antibody
Human peripheral blood monocytes were stained with purified ...
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