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PE anti-mouse IFN-γ Antibody

Pricing & Availability
Clone
XMG1.2 (See other available formats)
Regulatory Status
RUO
Other Names
Interferon-γ, Immune interferon, Type II interferon, T cell interferon, Macrophage-activating factor (MAF)
Isotype
Rat IgG1, κ
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Product Citations
publications
XMG1.2
PMA/Ionomycin-stimulated BALB/c T-cells were stained with CD3 FITC and XMG1.2 PE
  • XMG1.2
    PMA/Ionomycin-stimulated BALB/c T-cells were stained with CD3 FITC and XMG1.2 PE
Compare all formats See PE spectral data
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505807 25 µg £27
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505808 100 µg £76
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Description

IFN-γ is a potent multifunctional cytokine which is secreted primarily by activated NK cells and T cells. Originally characterized based on anti-viral activities, IFN-γ also exerts anti-proliferative, immunoregulatory, and proinflammatory activities. IFN-γ can upregulate MHC class I and II antigen expression by antigen-presenting cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
E. coli-expressed, recombinant mouse IFN-γ
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The IFN-γ antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

ELISA1-4,11,14 or ELISPOT5 Detection: The biotinylated XMG1.2 antibody is useful as a detection antibody for a sandwich ELISA or ELISPOT assay, when used in conjunction with purified R4-6A2 antibody (Cat. No. 505702/505706) as the capture antibody and recombinant mouse IFN-γ (Cat. No. 575309) as the standard.
ELISA or ELISPOT Capture: The purified XMG1.2 antibody is useful as a capture antibody for a sandwich ELISA or ELISPOT assay, when used in conjunction with biotinylated R4-6A2 antibody (Cat. No. 505704) as the detection antibody and recombinant mouse IFN-γ (Cat. No. 575309) as the standard. The LEAF™ purified antibody is suggested for ELISPOT capture (Cat. No. 505812).
Flow Cytometry7,8,12,13,16: The fluorochrome-labeled XMG1.2 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IFN-γ-producing cells within mixed cell populations.
Neutralization1-3,9,10: The XMG1.2 antibody can neutralize the bioactivity of natural or recombinant IFN-γ. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IFN-γ bioactivity in vivo and in vitro (Cat. No. 505812). For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 505834) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).
Additional reported applications (for the relevant formats) include: Western blotting, immunohistochemical staining of frozen tissue sections6,22,23, and immunocytochemistry.
Note: For testing mouse IFN-γ in serum, plasma or supernatant, BioLegend's ELISA Max™ Sets (Cat. No. 430801 to 430806) are specially developed and recommended.

Application References

(PubMed link indicates BioLegend citation)
  1. Abrams J, et al. 1992. Immunol. Rev. 127:5. (ELISA, Neut)
  2. Sander B, et al. 1993. J. Immunol. Meth. 166:201. (ELISA, Neut)
  3. Abrams J, et al. 1995. Curr. Prot. Immunol. John Wiley and Sons, New York. Unit 6.20. (ELISA, Neut)
  4. Yang X, et al. 1993. J. Immunoassay 14:129. (ELISA)
  5. Klinman D, et al. 1994. Curr. Prot. Immunol. John Wiley and Sons, New York. Unit 6.19. (ELISPOT)
  6. Sander B, et al. 1991. Immunol. Rev. 119:65. (IHC)
  7. Ferrick D, et al. 1995. Nature 373:255. (FC)
  8. Ko SY, et al. 2005. J. Immunol. 175:3309. (FC) PubMed
  9. Peterson KE, et al. 2000. J. Virol. 74:5363. (Neut)
  10. DeKrey GK, et al. 1998. Infect. Immun. 66:827. (Neut)
  11. Dzhagalov I, et al. 2007. J. Immunol. 178:2113. (ELISA)
  12. Lawson BR, et al. 2007. J. Immunol. 178:5366. (FC)
  13. Lee JW, et al. 2006. Nature Immunol. 8:181. (FC) PubMed
  14. Xu G, et al. 2007. J. Immunol. 179:5358. (ELISA) PubMed
  15. Montfort M, et al.2004. J. Immunol. 173:4084. PubMed
  16. Haring JS, et al. 2008. J. Immunol. 180:2855. (FC) PubMed
  17. Jordan JM, et al. 2008. Infect Immun. 76:3717. PubMed
  18. Tonkin DR, et al. 2008. J. Immunol. 181:4516. PubMed
  19. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  20. Cui Y, et al. 2009. Invest. Ophth. Vis. Sci. 50:5811. (FC) PubMed
  21. Mykkanen OT, et al. 2014. PLoS One. 9:114790. PubMed
  22. Yokogawa M, et al. 2013. Mol. Carcinog. 52:760. (IHC)
  23. Mottram PL, et al. 1998. J Immunol. 161:602. (IHC)
Product Citations
  1. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  2. Bradley CP et al. 2017. Cell host & microbe. 22(5):697-704 . PubMed
  3. Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed
  4. Toubai T, et al. 2017. Blood Adv. 1.095138889. PubMed
  5. Miki H, et al. 2020. J Immunol. 204:1892. PubMed
  6. Zhang H, et al. 2022. Eur J Immunol. 52:978. PubMed
  7. Jia JJ, et al. 2022. J Leukoc Biol. 112:157. PubMed
  8. Chakraborty P, et al. 2022. Cancer Res. 82:1969. PubMed
  9. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  10. Tu J, et al. 2022. Cancer Sci. 113:2496. PubMed
  11. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  12. Backlund C, et al. 2022. Proc Natl Acad Sci U S A. 119:e2204078119. PubMed
  13. Kang IH, et al. 2022. iScience. 25:104818. PubMed
  14. Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed
  15. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  16. Tan TCJ, et al. 2022. Nat Commun. 13:7796. PubMed
  17. Wang Z, et al. 2022. Cell Rep. 41:111890. PubMed
  18. Chan L, et al. 2022. Cells. 12: . PubMed
  19. Liu H, et al. 2023. Cell Death Differ. :. PubMed
  20. Mandour MF, et al. 2023. Front Med (Lausanne). 9:1057252. PubMed
  21. Kuehm LM, et al. 2021. Cancer Immunol Res. 9:227. PubMed
  22. Khojandi N, et al. 2021. Cancer Immunol Res. 9:214. PubMed
  23. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  24. Chen R, et al. 2022. J Mol Cell Biol. 14:. PubMed
  25. Cheng C, et al. 2022. Cell Mol Gastroenterol Hepatol. 15:261. PubMed
  26. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  27. Wang X, et al. 2023. J Immunother Cancer. 11:. PubMed
  28. Lu C, et al. 2023. Antiviral Res. 212:105556. PubMed
  29. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  30. Tan X, et al. 2023. Adv Sci (Weinh). 10:e2206768. PubMed
  31. Martins Nascentes Melo L, et al. 2023. J Immunother Cancer. 11:. PubMed
  32. Li D, et al. 2023. Ann Med. 55:2189295. PubMed
  33. Zuo B, et al. 2023. Clin Transl Oncol. . PubMed
  34. Pandit M, et al. 2023. Nat Commun. 14:2593. PubMed
  35. Yu L, et al. 2023. Front Oncol. 13:1174713. PubMed
  36. Deng G, et al. 2023. Cancers (Basel). 15:. PubMed
  37. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  38. Gao Y, et al. 2023. iScience. 26:106729. PubMed
  39. Vereertbrugghen A, et al. 2023. J Neuroinflammation. 20:120. PubMed
  40. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  41. Yang QC, et al. 2023. iScience. 26:106916. PubMed
  42. Tan L, et al. 2022. Aging Dis. 13:1562. PubMed
  43. Wang HH, et al. 2022. J Biomed Sci. 29:36. PubMed
  44. Wu MJ, et al. 2022. Cancer Discov. 12:812. PubMed
  45. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  46. Chen Y, et al. 2020. Virol Sin. . PubMed
  47. Sandu I, et al. 2020. Nat Commun. 11:4454. PubMed
  48. Wang H, et al. 2013. J Immunol. 191:6010. PubMed
  49. Kim K, et al. 2016. PLoS One. 11: 0148576. PubMed
  50. Lin W, et al. 2020. Theranostics. 10:4871. PubMed
  51. Zhou J, et al. 2019. Immunity. 50:403. PubMed
  52. Shi L, et al. 2019. Theranostics. 9:4115. PubMed
  53. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  54. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  55. Zhou J, et al. 2021. Int J Med Sci. 18:3516. PubMed
  56. Kim D, et al. 2021. Nanomicro Lett. 13:31. PubMed
  57. Gern BH, et al. 2021. Cell Host Microbe. 29(4):594-606.e6. PubMed
  58. Gálvez-Cancino F, et al. 2017. Vaccine. 10.1016/j.vaccine.2017.06.041. PubMed
  59. Wang X, et al. 2018. Int Immunopharmacol. 56:249. PubMed
  60. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
  61. Zhang S, et al. 2022. Cell Death Dis. 13:844. PubMed
  62. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  63. Stegelmeier AA, et al. 2022. Biomedicines. 10:. PubMed
  64. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  65. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  66. Coleby R, et al. 2021. Clin Exp Rheumatol. :39. PubMed
  67. Dong L, et al. 2021. Cancer Cell. . PubMed
  68. Yang F, et al. 2021. Front Microbiol. 11:512581. PubMed
  69. Xia S, et al. 2014. J Leukoc Biol. 95:733. PubMed
  70. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  71. Chakrabarti J, et al. 2018. Oncotarget. 9:37439. PubMed
  72. Oyarce C, et al. 2018. Front Immunol. 8:1794. PubMed
  73. Mayer RL, et al. 2022. Nat Commun. 13:6075. PubMed
  74. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  75. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  76. Herman JD, et al. 2021. Nat Commun. 12:6853. PubMed
  77. Galeano Niño JL, et al. 2020. J Cell Sci. . PubMed
  78. Saito S, et al. 2020. Nutrients. 12:. PubMed
  79. Tang Y, et al. 2020. Front Immunol. 11:585918. PubMed
  80. Koenecke C, et al. 2012. J Immunol. 189:2890. PubMed
  81. Chen D, et al. 2018. Nat Commun. 9:873. PubMed
  82. Papafragkos I, et al. 2022. Front Immunol. 13:889075. PubMed
  83. Xiong A, et al. 2022. EBioMedicine. 83:104239. PubMed
  84. Michel M, et al. 2012. Proc Natl Acad Sci U S A. 109:17459. PubMed
  85. Wang Y, et al. 2016. Sci Rep. 6:31881. PubMed
  86. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  87. Ning X, et al. 2019. Mol Cell. 74:19. PubMed
  88. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  89. Dai B, et al. 2022. Theranostics. 12:7603. PubMed
  90. Kuttke M, et al. 2022. Front Immunol. 13:695576. PubMed
  91. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  92. Subbiah J, et al. 2022. NPJ Vaccines. 7:68. PubMed
  93. Wang C, et al. 2021. Cell Rep. 37:110021. PubMed
  94. Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed
  95. Alissafi T, et al. 2020. Cell Metabolism. 32(4):591-604.e7. PubMed
  96. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  97. Uchil PD et al. 2018. Cell host & microbe. 25(1):87-100 . PubMed
  98. Probst P, et al. 2017. Cancer Res. 77:3644. PubMed
  99. Caronni N, et al. 2018. Cancer Res. 78:1685. PubMed
  100. Yu Y, et al. 2022. Nat Commun. 13:6357. PubMed
  101. An J, et al. 2022. iScience. 25:103570. PubMed
  102. Han JP, et al. 2022. Sci Adv. 8:eabj6901. PubMed
  103. Koren N, et al. 2021. Cell Host Microbe. 29(2):197-209.e5. PubMed
  104. Wan Y, et al. 2014. Vaccine. 41:241. PubMed
  105. Sandrock I, et al. 2015. PLoS One. 10: 0145010. PubMed
  106. Hegde S, et al. 2020. Cancer Cell. 37(3):289-307. PubMed
  107. Srey MT, et al. 2020. PLoS Negl Trop Dis. 14:e0008842. PubMed
  108. Chen D, et al. 2022. J Neuroinflammation. 19:112. PubMed
  109. Cha SE, et al. 2021. Oncoimmunology. 10:1899469. PubMed
  110. Canton J, et al. 2021. Nat Immunol. 22:140. PubMed
  111. Shami A, et al. 2015. Sci Rep. 5: 13904. PubMed
  112. Gungor B, et al. 2014. Sci Transl Med. 6:235. PubMed
  113. Hundt M, et al. 2009. J Immunol. 183:1685. PubMed
  114. Espinosa JR, et al. 2018. Front Immunol. 9:1371. PubMed
  115. Hanasoge Somasundara AV, et al. 2021. Cell Rep. 37:110099. PubMed
  116. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  117. Gong Y, et al. 2020. Cell Metabolism. 33(1):51-64.e9. PubMed
  118. Duan RN, et al. 2021. J Neuroinflammation. 18:145. PubMed
  119. Cho K, Hill A 2008. J Immunol Methods. 330:137. PubMed
  120. Condotta S, et al. 2015. J Immunol. 195: 116 - 125. PubMed
  121. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  122. Mirando AC, et al. 2020. Oncoimmunology. 9:1760685. PubMed
  123. Garo LP, et al. 2019. Cell Rep. 28:3353. PubMed
  124. Li W, et al. 2019. Nat Commun. 10:3349. PubMed
  125. Yan Y, et al. 2018. JCI Insight. 3. PubMed
  126. Place D, et al. 2017. PLoS One. 10.1371/journal.pone.0190384. PubMed
  127. Palazon A, et al. 2017. Cancer Cell. . 10.1016/j.ccell.2017.10.003. PubMed
  128. Reese B, et al. 2020. J Immunol. 205:3218. PubMed
  129. Brigas HC, et al. 2021. Cell Reports. 36(9):109574. PubMed
  130. Sartorius R, et al. 2015. EMBO Mol Med. 7: 973 - 988. PubMed
  131. Marcus A et al. 2018. Immunity. 49(4):754-763 . PubMed
  132. Bosnjak B, et al. 2021. Front Immunol. 12:772240. PubMed
  133. Tian X, et al. 2022. J Cell Mol Med. 26:693. PubMed
  134. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  135. Galeano Niño JL, et al. 2020. J Cell Sci. 133:00:00. PubMed
  136. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  137. Ma Y, et al. 2013. J Immunol. 190:5588. PubMed
  138. Dutow P, et al. 2014. J Infect Dis. 209:1269. PubMed
  139. QT N, et al. 2015. Antimicrob Agents Chemother. 59: 6308-6316. PubMed
  140. Latasa C, et al. 2016. PLoS One. 11: 0161216. PubMed
  141. Kraus Z, et al. 2008. J Immunol. 181:7800. PubMed
  142. Lin W, et al. 2019. EBioMedicine. 49:133. PubMed
  143. Leclerc M, et al. 2019. Nat Commun. 10:3345. PubMed
  144. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  145. Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed
  146. Yang Z, et al. 2021. Onco Targets Ther. 14:4239. PubMed
  147. De Ponte Conti B, et al. 2021. Elife. 10:. PubMed
  148. Tanaka Y, et al. 2020. Sci Rep. 10:17284. PubMed
  149. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  150. Lu J, et al. 2021. Cell Death Discov. 7:165. PubMed
  151. Yan J, et al. 2020. Cell Rep. 107820:31. PubMed
  152. Shen JZ, et al. 2020. Cell. 184(2):352-369.e23. PubMed
  153. Ren Y, et al. 2015. Sci Rep. 5: 18099. PubMed
  154. Bartolacci C, et al. 2018. Cancer Immunol Res. 1.281944444. PubMed
  155. Montfort M, et al. 2004. J Immunol. 173:4084. PubMed
  156. Karandikar SH, et al. 2019. JCI Insight. 5. PubMed
  157. Xu Q, et al. 2021. Theranostics. 11:1937. PubMed
  158. Guo S, et al. 2021. Sci Rep. 11:23745. PubMed
  159. Koelwyn GJ, et al. 2020. Nat Med. 1452:26. PubMed
  160. Xu P, et al. 2020. Cancer Immunol Res. 8:1193. PubMed
  161. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  162. Roy S, et al. 2019. Front Immunol. 2.404166667. PubMed
  163. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  164. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  165. Zhang J, et al. 2018. Nature. 553:91. PubMed
  166. Dong M, et al. 2022. J Immunother Cancer. 10:. PubMed
  167. Ye Q, et al. 2022. NPJ Vaccines. 7:84. PubMed
  168. Stephens WZ, et al. 2021. Cell Rep. 37:109916. PubMed
  169. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  170. Hirata SI, et al. 2020. Allergy. 75:1939. PubMed
  171. Castiglioni P, et al. 2017. PLoS Negl Trop Dis. 10.1371/journal.pntd.0005240. PubMed
  172. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  173. Mandour MF, et al. 2020. Infect Agent Cancer. 15:30. PubMed
  174. Li H, et al. 2021. Front Immunol. 12:739605. PubMed
  175. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  176. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  177. Miao W, et al. 2020. J Immunol. 1486:204. PubMed
  178. Cartwright ANR, et al. 2021. Cancer Immunol Res. 9:470. PubMed
  179. Lee J, et al. 2007. Nat Immunol. 8:181. PubMed
  180. Tian D, et al. 2019. Nat Commun. 10:4246. PubMed
  181. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  182. Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed
  183. Johnson RM, et al. 2021. Front Immunol. 11:614697. PubMed
  184. Mah-Som AY, et al. 2021. Cell Reports. 35(9):109209. PubMed
  185. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  186. Tomaru U et al. 2019. Cell reports. 26(3):639-651 . PubMed
  187. Wang Y, et al. 2021. Front Immunol. 11:601601. PubMed
  188. Prakash MD, et al. 2021. PLoS One. 16:e0247492. PubMed
  189. Zhang X, et al. 2020. J Cancer. 11:648. PubMed
  190. Molgora M, et al. 2020. Cell. 182:886. PubMed
  191. Fang W, et al. 2021. J Exp Clin Cancer Res. 40:4. PubMed
  192. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  193. Rousso-Noori L, et al. 2021. Nat Commun. 12:3615. PubMed
  194. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  195. Chakraborty P, et al. 2020. Cell Reports. 28(7):1879-1893.e7.. PubMed
  196. Nakao R, et al. 2022. NPJ Vaccines. 7:153. PubMed
  197. McAusland TM, et al. 2021. Mol Ther Oncolytics. 20:306. PubMed
  198. Li H, et al. 2022. iScience. 25:104481. PubMed
  199. Schmit T, et al. 2022. Cell Rep. 38:110456. PubMed
  200. Zhang X, et al. 2021. Front Pharmacol. 12:706748. PubMed
  201. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  202. Zhao K, et al. 2021. Biomed Res Int. 7619849:2020. PubMed
  203. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  204. Kim YS, et al. 2018. Front Immunol. 9:1093. PubMed
  205. Wang N, et al. 2020. Front Immunol. 1.765972222. PubMed
  206. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  207. Dourcy M, et al. 2020. Mucosal Immunol. 13:799. PubMed
  208. Kerdidani D, et al. 2022. J Exp Med. 219:. PubMed
  209. Zheng Y, et al. 2022. Transl Res. :. PubMed
  210. Gaylo A, et al. 2013. Transpl Immunol. 20:163. PubMed
  211. Brenner E, et al. 2020. Nat Commun. 11:1335. PubMed
  212. Qi S, et al. 2020. Theranostics. 10:1814. PubMed
  213. Chen S, et al. 2018. Nat Commun. 9:5298. PubMed
  214. Bing Wu et al. 2018. Immunity. 49(5):886-898 . PubMed
  215. Chen PM, et al. 2022. Sci Adv. 8:eabo4271. PubMed
  216. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  217. Yang F, et al. 2021. Nat Commun. 12:3424. PubMed
  218. Li X, et al. 2021. Front Cell Dev Biol. 9:647713. PubMed
  219. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  220. Chow AK, et al. 2021. Cellular and Molecular Gastroenterology and Hepatology. :. PubMed
  221. Tripathi D, et al. 2016. Nat Commun. 7:13896. PubMed
RRID
AB_315401 (BioLegend Cat. No. 505807)
AB_315402 (BioLegend Cat. No. 505808)

Antigen Details

Structure
Cytokine; dimer; 40-80 kD (Mammalian)
Bioactivity
Antiviral/antiparasitic activities; inhibits proliferation; enhances MHC class I and II expression on APCs
Cell Sources
CD8+ and CD4+ T cells, NK cells
Cell Targets
T cells, B cells, macrophages, NK cells, endothelial cells, fibroblasts
Receptors
IFN-γRα (CDw119) dimerized with IFN-γRβ (AF-1)
Cell Type
Tregs
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego.
2. De Maeyer E, et al. 1992. Curr. Opin. Immunol. 4:321.
3. Farrar M, et al. 1993. Annu. Rev. Immunol. 11:571.
4. Gray P, et al. 1987. Lymphokines 13:151.

Regulation
Upregulated by IL-2, FGF-basic, EGF; downregulated by 1-α-25-Dihydroxy vitamin D3, dexamethasone
Gene ID
15978 View all products for this Gene ID
UniProt
View information about IFN-gamma on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
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For Research Use Only. Not for diagnostic or therapeutic use.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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