Loading...

PE/Cyanine7 anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
M1slash70_PECy7_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE/Cyanine7 (filled histogram) or rat IgG2b, κ PE/Cyanine7 isotype control (open histogram) (gated on total cells).
  • M1slash70_PECy7_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE/Cyanine7 (filled histogram) or rat IgG2b, κ PE/Cyanine7 isotype control (open histogram) (gated on total cells).
Compare all formats See PE/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability Save
101215 25 µg £60
Check Availability


Need larger quantities of this item?
Request Bulk Quote
101216 100 µg £145
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. D'Alessandro G, et al. 2020. Eur J Immunol. 50:705. PubMed
  2. DeSouza-Vieira T, et al. 2020. Cell Rep. 33:108317. PubMed
  3. Gogoi H, et al. 2020. Front Immunol. 1.620833333. PubMed
  4. Liu K, et al. 2021. Cell Metabolism. 33(3):666-675.e4. PubMed
  5. Wang L, et al. 2021. J Nanobiotechnology. 19:56. PubMed
  6. Parsons M, et al. 2014. J Immunol. 192:1361. PubMed
  7. Tebartz C, et al. 2015. J Immunol. 194:1100. PubMed
  8. Quispe Calla N, et al. 2016. Sci Rep. 6:37723. PubMed
  9. Denny L, et al. 2021. Clin Transl Immunology. 10:e1234. PubMed
  10. Janbandhu V, et al. 2022. Cell Stem Cell. 29:281. PubMed
  11. Cohen K, et al. 2021. Cell Rep. 37:110026. PubMed
  12. Aimaitijiang A, et al. 2022. Genes Cells. 27:25. PubMed
  13. Schnell A, et al. 2021. Cell. 184:6281. PubMed
  14. Zhou Y, et al. 2022. Br J Pharmacol. 179:1978. PubMed
  15. Hiyoshi H, et al. 2022. Cell Host Microbe. 30:163. PubMed
  16. Wang B, et al. 2022. EMBO J. 41:e108946. PubMed
  17. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  18. Du Y, et al. 2022. J Exp Med. 219: . PubMed
  19. Pannunzio B, et al. 2022. Cells. 11: . PubMed
  20. Marié IJ, et al. 2022. Bio Protoc. 12:e4438. PubMed
  21. Hong Y, et al. 2022. J Leukoc Biol. 112:425. PubMed
  22. Que W, et al. 2022. Sci Adv. 8:eabo4413. PubMed
  23. Liu Z, et al. 2022. Cancer Commun (Lond). 42:971. PubMed
  24. Zhang X, et al. 2022. EBioMedicine. 84:104275. PubMed
  25. Hindy G, et al. 2022. J Clin Invest. 132: . PubMed
  26. Lu Z, et al. 2022. Cell Rep. 41:111482. PubMed
  27. Mansouri S, et al. 2022. J Immunol. 209:2114. PubMed
  28. Yoo HJ, et al. 2022. Cell Rep. 41:111598. PubMed
  29. Papaxenopoulou LA, et al. 2022. iScience. 25:105522. PubMed
  30. Zhang Y, et al. 2022. Front Oncol. 12:1042250. PubMed
  31. He Y, et al. 2022. Front Immunol. 13:986202. PubMed
  32. Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed
  33. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  34. Choi H, et al. 2023. J Nanobiotechnology. 21:5. PubMed
  35. Wang D, et al. 2023. J Exp Clin Cancer Res. 42:26. PubMed
  36. Leinenga G, et al. 2023. Bioeng Transl Med. 8:e10329. PubMed
  37. Wang R, et al. 2023. iScience. 26:105954. PubMed
  38. Slusarczyk P, et al. 2023. Elife. 12: . PubMed
  39. Ernst MPT, et al. 2023. Hemasphere. 7:e824. PubMed
  40. Drijvers JM, et al. 2021. Cancer Immunol Res. 9:184. PubMed
  41. Yeh CH, et al. 2022. Immunity. 55:272. PubMed
  42. Sheng YH, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:789. PubMed
  43. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  44. Mela V, et al. 2023. Mol Neurobiol. 60:3044. PubMed
  45. Schönberger K, et al. 2023. Anal Chem. 95:4325. PubMed
  46. Li L, et al. 2023. iScience. 26:106095. PubMed
  47. Tang C, et al. 2023. Nat Commun. 14:1493. PubMed
  48. Gupta T, et al. 2023. Front Immunol. 14:1044703. PubMed
  49. MacPherson KP, et al. 2023. Front Cell Neurosci. 17:895017. PubMed
  50. Martins Nascentes Melo L, et al. 2023. J Immunother Cancer. 11:. PubMed
  51. Pastrez PRA, et al. 2023. Cancers (Basel). 15:. PubMed
  52. Yao H, et al. 2023. Front Immunol. 14:1147674. PubMed
  53. Hernandez VG, et al. 2023. Glia. 71:1960. PubMed
  54. Kim BH, et al. 2023. Sci Rep. 13:6577. PubMed
  55. Lu Y, et al. 2023. J Transl Med. 21:339. PubMed
  56. Bobadilla Muñoz M, et al. 2023. Front Cell Dev Biol. 11:1128534. PubMed
  57. Doloff JC, et al. 2023. Sci Adv. 9:eade9488. PubMed
  58. Ye S, et al. 2023. Front Oncol. 13:1202750. PubMed
  59. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  60. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  61. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  62. Cheresh P, et al. 2021. Int J Mol Sci. 22:. PubMed
  63. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  64. Odom CV, et al. 2021. J Immunol. 207:1891. PubMed
  65. Hatzi K, et al. 2019. Nat Immunol. 20:86. PubMed
  66. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  67. Lin C et al. 2019. Immunity. 50(1):137-151 . PubMed
  68. Okunuki Y, et al. 2018. Proc Natl Acad Sci U S A. 115:E6264. PubMed
  69. Li Z, et al. 2021. Immunology. 163:105. PubMed
  70. Correa S, et al. 2020. ACS Nano. 14:2224. PubMed
  71. Kim JS, et al. 2020. Immunity. 54(1):176-190.e7. PubMed
  72. Gazit R, et al. 2014. J Exp Med. 211:1315. PubMed
  73. Kitagawa S, et al. 2022. NPJ Vaccines. 7:115. PubMed
  74. Giorgetti E, et al. 2020. Cell Reports. 29(6):1539-1554.e7.. PubMed
  75. Thelin MA, et al. 2017. Diabetes. 66:2220. PubMed
  76. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  77. Jung MY, et al. 2022. Neurooncol Adv. 4:vdac017. PubMed
  78. Schönberger K, et al. 2022. Cell Stem Cell. 29:131. PubMed
  79. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  80. Sharma GP, et al. 2021. PLoS One. 16:e0259042. PubMed
  81. Zhang LJ, et al. 2019. Immunity. 50:121. PubMed
  82. Abels ER et al. 2019. Cell Rep. 28(12):3105-3119 . PubMed
  83. Frisbee AL, et al. 2019. Nat Commun. 10:2712. PubMed
  84. Groza D, et al. 2018. Oncoimmunology. 7:e1424676. PubMed
  85. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  86. Iwamoto H et al. 2018. Cell metabolism. 28(1):104-117 . PubMed
  87. McGill BE et al. 2018. The Journal of Neuroscience. 38(1):200-219 . PubMed
  88. Zheng W, et al. 2021. Wellcome Open Research. 6:52. PubMed
  89. Mogilenko DA, et al. 2020. Immunity. 54(1):99-115.e12. PubMed
  90. Riether C, et al. 2021. Cell Reports. 34(4):108663. PubMed
  91. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  92. Wei H, et al. 2021. Malar J. 20:89. PubMed
  93. Van Den Eeckhout B, et al. 2020. NPJ Vaccines. 5:64. PubMed
  94. Hickey A, et al. 2021. Front Microbiol. 12:653587. PubMed
  95. Radovanovic I, et al. 2014. J Immunol. 193:1290. PubMed
  96. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  97. Delás MJ, et al. 2019. Cell Rep. 27:719. PubMed
  98. Morgan PK, et al. 2021. J Biol Chem. 297:101341. PubMed
  99. Yang C, et al. 2021. J Immunother Cancer. 9:. PubMed
  100. Piepke M, et al. 2021. J Neuroinflammation. 18:265. PubMed
  101. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  102. Chen T, et al. 2021. JCI Insight. 6:. PubMed
  103. Kurelac I, et al. 2019. Nat Commun. 10:903. PubMed
  104. Kobayashi Y, et al. 2018. PLoS One. 13:e0195008. PubMed
  105. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  106. Yang X, et al. 2020. Blood Sci. 2:89. PubMed
  107. Deslyper G, et al. 2021. Parasitology. 148:539. PubMed
  108. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  109. Saggu G, et al. 2018. Nat Commun. 9:5058. PubMed
  110. Yuzhu Hou et al. 2018. Immunity. 49(3):490-503 . PubMed
  111. Bowers E, et al. 2018. Nat Med. 24:95. PubMed
  112. Shemer A, et al. 2020. Immunity. 53(5):1033-1049.e7. PubMed
  113. Yamamoto K, et al. 2021. Cell Reports. 36(8):109576. PubMed
  114. Uroda T, et al. 2020. Nat Protoc. 15:2107. PubMed
  115. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  116. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  117. Zong L, et al. 2021. NPJ Aging Mech Dis. 7:25. PubMed
  118. Martin R, et al. 2014. J Leukoc Biol. 96:151. PubMed
  119. Royzman D, et al. 2022. Front Immunol. 13:1012647. PubMed
  120. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  121. Somerville TD, et al. 2020. eLife. 9:e53381.. PubMed
  122. Almutairi F, et al. 2021. Front Immunol. 12:772288. PubMed
  123. Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
  124. Akhmetzyanova ER, et al. 2019. Front Cell Neurosci. 12:507. PubMed
  125. Lubkin A et al. 2019. Cell host & microbe. 25(3):463-470 . PubMed
  126. Gibson EM, et al. 2019. Cell. 176:43:00. PubMed
  127. Juttukonda LJ, et al. 2017. Cell Host Microbe. 22:531. PubMed
  128. Super M, et al. 2021. Nat Biomed Eng. Online ahead of print. PubMed
  129. Kulkarni NN, et al. 2021. J Biol Chem. 297:100828. PubMed
  130. Jia X, et al. 2021. Front Cell Dev Biol. 9:685522. PubMed
  131. Klopfenstein N, et al. 2021. PLoS Pathog. 17:e1009387. PubMed
  132. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  133. Vazquez S, et al. 2015. Exp Hematol. 43: 578-585. PubMed
  134. Shade K, et al. 2015. J Exp Med. 212:457. PubMed
  135. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  136. Walker FC, et al. 2021. PLoS Pathog. 17:e1009402. PubMed
  137. Johansen AZ, et al. 2022. Pharmaceutics. 14:. PubMed
  138. Liu Y, et al. 2022. Nat Commun. 13:2665. PubMed
  139. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  140. Dodagatta-Marri E, et al. 2021. Cell Rep. 36:109309. PubMed
  141. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  142. Angelidis I, et al. 2019. Nat Commun. 10:963. PubMed
  143. Kohn M, et al. 2021. Front Immunol. 580594:12. PubMed
  144. Liang Z, et al. 2020. Pain. 161:2089. PubMed
  145. Hore ZL, et al. 2021. Wellcome Open Res. 6:68. PubMed
  146. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  147. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  148. Meeks K, et al. 2009. J Immunol. 183:8026. PubMed
  149. Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
  150. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  151. Vasilijevic J, et al. 2017. PLoS Pathog. 13:e1006650. PubMed
  152. Pan YC, et al. 2021. Mol Ther Oncolytics. 20:175. PubMed
  153. Aegerter H, et al. 2020. Nat Immunol. 0.975694444. PubMed
  154. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  155. Kirschbaum K, et al. 2016. Proc Natl Acad Sci U S A. 113: 13227 - 13232. PubMed
  156. Amo-Aparicio J, et al. 2021. Theranostics. 11:9805. PubMed
  157. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  158. Goldman E, et al. 2021. Cells. 10:. PubMed
  159. Dokoshi T, et al. 2021. J Clin Invest. 131:. PubMed
  160. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  161. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  162. Xie Z, et al. 2020. Light Sci Appl. 0.486805556. PubMed
  163. Gomzikova MO, et al. 2020. Sci Rep. 10:10740. PubMed
  164. He Y, et al. 2021. Cell Metabolism. 33(5):988-1000.e7. PubMed
  165. Okubo K, et al. 2021. Cell Reports. 35(7):109142. PubMed
  166. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  167. Huang YL, et al. 2021. Commun Biol. 4:229. PubMed
  168. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  169. Synn CB, et al. 2022. Clin Transl Immunology. 11:e1364. PubMed
  170. Kooreman NG et al. 2018. Cell stem cell. 22(4):501-513 . PubMed
  171. Proto JD et al. 2018. Immunity. 49(4):666-677 . PubMed
  172. Secondini C, et al. 2017. Oncoimmunology. 6:e1316437. PubMed
  173. Wang D, et al. 2021. Nat Commun. 12:2674. PubMed
  174. Jia Q, et al. 2021. Theranostics. 4699:11. PubMed
  175. Dobosz E, et al. 2021. Dis Model Mech. :14. PubMed
  176. Mulas F, et al. 2020. Cell Mol Immunol. . PubMed
  177. Zhu H, et al. 2021. Cell Metabolism. :. PubMed
  178. Bambouskova M, et al. 2021. Cell Reports. 34(10):108756. PubMed
  179. Ringel AE, et al. 2020. Cell. 183(7):1848-1866.e26. PubMed
  180. Pérez-Girón J, et al. 2015. J Vis Exp. 100: 52803. PubMed
  181. Suresh MV, et al. 2019. JCI Insight. 4:e133103. PubMed
  182. Patel S, et al. 2019. Viruses. 0.877083333. PubMed
  183. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  184. Uddin MJ, et al. 2022. Mucosal Immunol. 15:165. PubMed
  185. Bradley KC, et al. 2019. Cell Rep. 28:245. PubMed
  186. Kumar MP, et al. 2018. Cell Rep. 25:1458. PubMed
  187. Steuerman Y et al. 2018. Cell systems. 6(6):679-691 . PubMed
  188. Trefzer A, et al. 2021. Cell Reports. 34(6):108748. PubMed
  189. Lim CX, et al. 2020. Cell Rep. 3793:30. PubMed
  190. Boulay A, et al. 2015. J Neurosci. 35:4427. PubMed
  191. Liu H, et al. 2022. Front Pharmacol. 13:949316. PubMed
  192. Wilson DH, et al. 2020. Nat Commun. 0.767361111. PubMed
  193. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  194. Endoh M, et al. 2020. Cell Reports. 30(6):1823-1834. PubMed
  195. Li H, et al. 2020. Nature. 584:274. PubMed
  196. Sibilio A, et al. 2022. iScience. 25:103790. PubMed
  197. Dey S, et al. 2020. J Immunother Cancer. 8:. PubMed
  198. Shen M, et al. 2022. Nat Cancer. 3:60. PubMed
  199. Li Z, et al. 2018. Front Immunol. 9:347. PubMed
  200. Marcus A et al. 2018. Immunity. 49(4):754-763 . PubMed
  201. Van Winkle JA et al. 2018. Cell host & microbe. 24(5):665-676 . PubMed
  202. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  203. Monaghan KL, et al. 2020. J Vis Exp. . PubMed
  204. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  205. Crouse B, et al. 2020. NPJ Vaccines. 0.277083333. PubMed
  206. Lee L, et al. 2016. PLoS One. 11:e0167693. PubMed
  207. Arce-Cerezo A, et al. 2015. Sci Rep. 5: 1448. PubMed
  208. Ballet R, et al. 2014. PLoS Pathog. 10:1004550. PubMed
  209. Choi EW, et al. 2020. Sci Rep. 10:12001. PubMed
  210. Denny JE, et al. 2019. Sci Rep. 2.786111111. PubMed
  211. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  212. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  213. Gao C, et al. 2017. Mol Neurobiol.. 10.1007/s12035-016-0318-0. PubMed
  214. Khare P, et al. 2017. J Autoimmun. 10.1016/j.jaut.2017.09.002. PubMed
  215. Koelwyn GJ, et al. 2020. Nat Med. 1452:26. PubMed
  216. Kim SJ, et al. 2020. Cell Mol Immunol. 17:728. PubMed
  217. Scholz F, et al. 2015. J Immunol. 195: 2335-2342. PubMed
  218. Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
  219. Mohamed E, et al. 2020. Immunity. 52(4):668-682.e7.. PubMed
  220. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  221. Merrell AJ, et al. 2021. Hepatology. 74:444. PubMed
  222. Chen C, et al. 2021. J Virol. 95:e0082921. PubMed
  223. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  224. Robinett RA et al. 2018. Cell systems. 7(1):41-48 . PubMed
  225. Nahrendorf W, et al. 2021. eLife. 10:00. PubMed
  226. Mansouri S, et al. 2020. Mucosal Immunol. 0.954861111. PubMed
  227. Sasaki Y, et al. 2015. PLoS One. 10: 0131176. PubMed
  228. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  229. Burgener SS, et al. 2019. Cell Rep. 27:3646. PubMed
  230. Zhang CR, et al. 2022. Blood Cancer Discov. 3:220. PubMed
  231. Takaku S, et al. 2022. Evid Based Complement Alternat Med. 2022:6122955. PubMed
  232. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  233. Wang W, et al. 2021. J Am Heart Assoc. 10:e019142. PubMed
  234. Song J, et al. 2021. Am J Physiol Heart Circ Physiol. 320:H323. PubMed
  235. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  236. Duarte D, et al. 2018. Cell Stem Cell. 22:64. PubMed
  237. Kobia FM, et al. 2020. PLoS Biol. 18:e3000850. PubMed
  238. Bordas M, et al. 2020. Int J Mol Sci. 21:00. PubMed
  239. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  240. Jiang L, et al. 2020. Cell. 183(5):1219-1233.e18. PubMed
  241. Onai N, et al. 2020. Int J Mol Sci. :22. PubMed
  242. Ivan DC, et al. 2021. Front Immunol. 12:666961. PubMed
  243. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  244. Richardson ET, et al. 2015. PLoS One. 10: 1371. PubMed
  245. Moro T, et al. 2016. PLoS One. 11: 0146592. PubMed
  246. Njock MS, et al. 2022. J Extracell Vesicles. 11:e12228. PubMed
  247. Yousef H, et al. 2019. Nat Med. 25:988. PubMed
  248. Franklin DA, et al. 2020. JCI Insight. 5:. PubMed
  249. Omatsu Y, et al. 2022. Nat Commun. 13:2654. PubMed
  250. Liu W, et al. 2022. J Clin Invest. 132: . PubMed
  251. Schönberger K, et al. 2022. STAR Protoc. 3:101408. PubMed
  252. Celik H, et al. 2018. Cancer Cell. 34:741. PubMed
  253. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  254. Johnson RM, et al. 2021. Front Immunol. 11:614697. PubMed
  255. Kiss M, et al. 2020. Cancer Immunol Res. 9:309. PubMed
  256. Gourvest M, et al. 2021. Leukemia. . PubMed
  257. Bagati A, et al. 2020. Cancer Cell. 39(1):54-67.e9. PubMed
  258. Gicheva N, et al. 2016. Biochem Biophys Res Commun. 479:1-4. PubMed
  259. Beauchamp N, et al. 2010. J Virol. 84:10191. PubMed
  260. Wang Y, et al. 2020. eLife. 9:e57438.. PubMed
  261. Yu L, et al. 2020. Nat Commun. 2.045833333. PubMed
  262. Sadhu S, et al. 2021. J Immunol. 207:1812. PubMed
  263. Sun L, et al. 2022. Adv Sci (Weinh). 9:e2104051. PubMed
  264. Canedo T, et al. 2021. Neuropsychopharmacology. 46:2358. PubMed
  265. McKenzie MD, et al. 2019. Cell Stem Cell. 25:258. PubMed
  266. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  267. Contreras NA, et al. 2019. PLoS Pathog. 15:e1007890. PubMed
  268. Cantor DJ et al. 2019. Cell reports. 26(1):108-118 . PubMed
  269. Baratin M, et al. 2017. Immunity. 47:349. PubMed
  270. Coley WD et al. 2018. F1000Research. 2018 Mar 14 [revised 2018 Jan 1] 0.5125. PubMed
  271. Zhao N, et al. 2018. J Clin Invest. 26:84. PubMed
  272. Tsunekuni K, et al. 2020. J Clin Med. 9:00. PubMed
  273. Huang WC, et al. 2020. Adv Mater. 32:e2005637. PubMed
  274. Shin M, et al. 2020. Cell Chem Biol. 314:27. PubMed
  275. Kaiser S, et al. 2020. Glia. 68:2427. PubMed
  276. Aggio-Bruce R, et al. 2020. Mol Neurobiol. . PubMed
  277. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  278. Molgora M, et al. 2020. Cell. 182:886. PubMed
  279. McPhee C, et al. 2013. J Immunol. 191:4581. PubMed
  280. Fujimura N, et al. 2016. Sci Rep. 5:11664. PubMed
  281. Rosen DA, et al. 2019. Sci Transl Med. 11:eaau5266. PubMed
  282. Dokoshi T, et al. 2020. Cell Rep. 30:61. PubMed
  283. Van Den Eeckhout B, et al. 2020. NPJ Vaccines. 0.252777778. PubMed
  284. Süß P, et al. 2020. Cell Reports. 30(12):4082-4095. PubMed
  285. Shi J, et al. 2022. Front Pharmacol. 12:818326. PubMed
  286. Asada S, et al. 2018. Nat Commun. 9:2733. PubMed
  287. Kong XF, et al. 2018. Nat Immunol. 19:973. PubMed
  288. Gao P, et al. 2020. Front Immunol. 1.636111111. PubMed
  289. Chen S, et al. 2015. Cancer Res . 7: 519-531. PubMed
  290. Groppa E, et al. 2015. EMBO Mol Med. 2015; 7: 1366 - 1384. PubMed
  291. Gharib S, et al. 2014. J Leukoc Biol. 95:9. PubMed
  292. Alfaro M, et al. 2008. Proc Natl Acad Sci U S A. 105:18366. PubMed
  293. Liu G, et al. 2022. Theranostics. 12:2248. PubMed
  294. Fan HH, et al. 2021. Methods Mol Biol. 2276:203. PubMed
  295. Monteiro LB, et al. 2020. MethodsX. 7:100938. PubMed
  296. Rodriguez-Tirado C, et al. 2022. Cancers (Basel). 14:. PubMed
  297. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  298. Harding CL, et al. 2020. Front Cell Infect Microbiol. 10:328. PubMed
  299. Chavez JS, et al. 2022. Cells. 11:. PubMed
  300. Boulch M, et al. 2021. Sci Immunol. 6:. PubMed
  301. Walker JA, et al. 2020. Immunity. 51(1):104-118. PubMed
  302. Winter C, et al. 2018. Cell Metab. 28:175. PubMed
  303. Tippimanchai DD, et al. 2018. Oncoimmunology. 7:e1438105. PubMed
  304. Akhand SS, et al. 2020. Cancer Immunol Res. 8:1542. PubMed
  305. Xu G, et al. 2015. Free Radic Biol Med. 87: 15-25. PubMed
  306. Zhang S, et al. 2016. PLoS Pathog. 12: 1005617. PubMed
  307. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  308. Wang L, et al. 2020. J Nanobiotechnology. 18:38. PubMed
  309. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  310. Franklin R, et al. 2022. Nat Commun. 13:2350. PubMed
  311. Gawish R, et al. 2022. Elife. 11:. PubMed
  312. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  313. Severe N et al. 2019. Cell Stem Cell. 25(4):570-583 . PubMed
  314. Xie Z, et al. 2020. Light Sci Appl. 9:161. PubMed
  315. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  316. Young K, et al. 2021. Cell Stem Cell. . PubMed
  317. Lucas ED, et al. 2020. Cell Reports. 33(2):108258. PubMed
  318. Zysset D, et al. 2016. Nat Commun. 7:13151. PubMed
  319. Cai T, et al. 2022. Front Immunol. 13:1009932. PubMed
  320. Scheyltjens I, et al. 2022. Nat Protoc. 17:2354. PubMed
  321. Huanga J, et al. 2013. J Immunol Methods. 387:254. PubMed
  322. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  323. Qi S, et al. 2020. Theranostics. 10:1814. PubMed
  324. Zheng W, et al. 2019. Cell Rep. 29:1747. PubMed
  325. Zhang Y, et al. 2022. J Immunother Cancer. 10:. PubMed
  326. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
  327. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  328. Lalor R, et al. 2019. Nutrients. 11. PubMed
RRID
AB_312798 (BioLegend Cat. No. 101215)
AB_312799 (BioLegend Cat. No. 101216)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD11b
Specificity Alt (DOES NOT SHOW ON TDS):
CD11b
App Abbreviation (DOES NOT SHOW ON TDS):
FC
Hidden Names (DOES NOT SHOW ON TDS):
aM integrin, alpha integrin, alphaM integrin, alpha M integrin, integrin alphaM, integrin aM, integrin alpha M, CD11, Macrophage, Myeloid Dendritic Cell, Neutrophil, NK Cell, Plasmacytoid Dendritic Cell, Microglia
UniProt
View information about CD11b on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Spark PLUS B550™ anti-mouse/human CD11b M1/70 FC
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account