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Purified anti-human ANTXR2 Antibody

Pricing & Availability
Clone
H8R23 (See other available formats)
Regulatory Status
RUO
Other Names
Capillary morphogenesis gene 2 (CMG2)
Isotype
Mouse IgG1, κ
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Product Citations
publications
H8R23_PURE_ANTIXR2_Antibody_090420.png
Human peripheral blood monocytes were stained with anti-human CD16 Alexa Fluor® 700 and purified anti-human ANTXR2 (clone H8R23) (left) or mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE . Dot plots are gated on monocyte population.
  • H8R23_PURE_ANTIXR2_Antibody_090420.png
    Human peripheral blood monocytes were stained with anti-human CD16 Alexa Fluor® 700 and purified anti-human ANTXR2 (clone H8R23) (left) or mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE . Dot plots are gated on monocyte population.
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318402 100 µg 338€
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Description

ANTXR2, also known as anthrax toxin receptor 2, is a type I transmembrane protein with an extracellular von Willebrand factor A (vWA) domain, an immunoglobulin (Ig)-like domain, a single transmembrane helix and a cytoplasmic tail. It binds to the Bacillus anthracis toxin subunit, protective antigen (PA), in a divalent cation-dependent manner. Upon binding of PA, multiple toxin-receptor complexes assemble in lipid rafts, which are then internalized. This results in the formation of a pore in the endosomal membrane, enabling the escape of other anthrax toxin subunits into the cytoplasm. Additionally, ANTXR2 interacts with laminin, and possibly collagen type IV, suggesting a role for this receptor in capillary formation and basement membrane assembly.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
HCC827 GR2 cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2876621 (BioLegend Cat. No. 318402)

Antigen Details

Structure
Type I transmembrane protein, with an extracellular van Willebrand factor A (vWA) domain, an Ig-like domain, a single transmembrane helix and a cytoplasmic tail. 54 kD.
Distribution

ANTXR2 is expressed on T cell, B cell, dendritic cell, monocytes, and granulocytes.

Function
The ANTXR2 protein acts as a receptor for the toxin that causes anthrax, allowing the toxin to attach to cells and trigger disease. The ANTXR2 protein is also involved in the formation of capillaries and maintaining the structure of basement membranes.
Ligand/Receptor
Protective antigen (PA), laminin, collagen type IV
Cell Type
B cells, Dendritic cells, Granulocytes, Monocytes, T cells
Biology Area
Bacterial proteins and Toxins
Molecular Family
Adhesion Molecules
Antigen References
  1. Burgi J, et al. 2017. Nature Comms. 8:15861
  2. Scobie H, et al. 2003. Proc. Natl. Acad. Sci. USA. 100:5170
Gene ID
118429 View all products for this Gene ID
UniProt
View information about ANTXR2 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09.04.2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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