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APC anti-human CD158k (KIR3DL2) Antibody

Pricing & Availability
Clone
S22025B (See other available formats)
Regulatory Status
RUO
Other Names
NKAT4, Killer Cell Immunoglobulin-Like Receptor 3DL2
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
S22025B_APC_CD158k_Antibody_1_021225
Human peripheral blood lymphocytes were stained with anti-human CD56 (clone QA17A16) FITC and anti-human CD158k (KIR3DL2) (clone S22025B) APC (left) or mouse IgG1, κ APC isotype control (right).
  • S22025B_APC_CD158k_Antibody_1_021225
    Human peripheral blood lymphocytes were stained with anti-human CD56 (clone QA17A16) FITC and anti-human CD158k (KIR3DL2) (clone S22025B) APC (left) or mouse IgG1, κ APC isotype control (right).
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389605 25 tests 157€
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389606 100 tests 320€
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Description

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 15 polymorphic KIR genes have been reported in humans. CD158k is a 70 kD three extracellular Ig domain glycoprotein that presents as a disulphide-bonded homodimer extracellularly. The intracellular long cytoplasmic tail of CD158k contains two ITIM domains. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR3DL2 binds to a number of different MHC class 1 molecules depending on the viral peptide sequence presented.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
KIR3DL2-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Based on in-house testing on different KIR-expressing transfectants, clone S22025B does not interact with other KIR protein family members.

Antigen Details

Structure
70 kD three Ig-like extracellular domain glycoprotein
Distribution

Subset of NK cells, subset of T cells

Function
NK Cell regulation
Ligand/Receptor
MHC Class 1 molecules
Cell Type
Lymphocytes, NK cells, T cells
Biology Area
Cell Biology, Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References
  1. Colonna M. et al. 1995. Science. 268:405-8.
  2. Lanier LL. 2005. Annu Rev Immunol. 23:225-74.
  3. Hansasuta P, et al. 2004. Eur J immunol. 34:1673-9.
Gene ID
3812 View all products for this Gene ID
UniProt
View information about CD158k on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 02.12.2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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