Loading...

Purified anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
1-M1slash70_Purified_042706
C57BL/6 mouse bone marrow cells were stained with purified CD11b (clone M1/70) (filled histogram) or rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG FITC (gated on total cells).
  • 1-M1slash70_Purified_042706
    C57BL/6 mouse bone marrow cells were stained with purified CD11b (clone M1/70) (filled histogram) or rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG FITC (gated on total cells).
  • 2-M170_Pure_CD11b_Antibody_IHC_102418
    Fresh, frozen mouse spleen was stained with purified CD11b clone M1/70 conjugated and detected with a Cy5 CODEX™ oligonucleotide duplex (red). Samples were counterstained with TCR FITC (green). Data generated at Akoya Biosciences, Inc. using the CODEX™ technology.
Compare all formats
Cat # Size Price Quantity Check Availability Save
101201 50 µg 24€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
101202 500 µg 92€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F, CyTOF® - Verified
IP, ICC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  2. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  3. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  4. Doll JR, et al. 2020. PLoS Pathog. 16:e1008296. PubMed
  5. Yu H, et al. 2020. Front Immunol. 11:1773. PubMed
  6. Cai S, et al. 2020. Sci Rep. 10:14249. PubMed
  7. Calcagno DM, et al. 2020. Sci Immunol. 5: . PubMed
  8. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  9. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  10. Moore J, et al. 2022. Cancer Res. 82:365. PubMed
  11. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  12. Xiong T, et al. 2022. Cancer Sci. 113:1955. PubMed
  13. Campisi L, et al. 2022. Nature. 606:945. PubMed
  14. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  15. Zhao J, et al. 2022. J Clin Invest. 132: . PubMed
  16. Gavish A, et al. 2023. iScience. 26:105826. PubMed
  17. Jiang L, et al. 2021. Nano Today. 36:. PubMed
  18. Potempa M, et al. 2022. J Immunol. 208:1742. PubMed
  19. Shirai T, et al. 2022. Cancer Sci. 113:3710. PubMed
  20. Chen W, et al. 2023. JCI Insight. 8:. PubMed
  21. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  22. Kang YA, et al. 2023. J Exp Med. 220:. PubMed
  23. Diray-Arce J, et al. 2023. Cell Rep Med. 4:101079. PubMed
  24. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  25. Wolf Y, et al. 2017. J Exp Med. 214:905. PubMed
  26. Taki M, et al. 2018. Nat Commun. 1.545138889. PubMed
  27. Vinaik R, et al. 2019. Am J Physiol Endocrinol Metab. 317:E751. PubMed
  28. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  29. Paterson MJ, et al. 2020. PLoS Pathog. 16:e1008733. PubMed
  30. Peterson EJ, et al. 2019. Mol Syst Biol. 15:e8584. PubMed
  31. Axelrod HD, et al. 2019. Mol Cancer Res. 17:356. PubMed
  32. Tong CF, et al. 2018. Am J Physiol Cell Physiol. 315:C409. PubMed
  33. Zhao J, et al. 2021. JCI Insight. 6:. PubMed
  34. Larson-Casey JL, et al. 2021. FASEB J. 35:e21675. PubMed
  35. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  36. Reglero-Real N, et al. 2021. Immunity. :. PubMed
  37. Weidner H, et al. 2020. JCI Insight. 5:00. PubMed
  38. Yonemitsu K, et al. 2022. Sci Rep. 12:12007. PubMed
  39. Kim D, et al. 2008. Blood. 112:1109. PubMed
  40. Mazor R, et al. 2018. Proc Natl Acad Sci U S A. 115:E733. PubMed
  41. Pilling D, et al. 2022. Respir Res. 23:215. PubMed
  42. Bajaña S, et al. 2021. Front Immunol. 11:577718. PubMed
  43. Chung MI, et al. 2018. Am J Respir Cell Mol Biol. 59:706. PubMed
  44. Burrello C, et al. 2018. Front Med (Lausanne). 5:21. PubMed
  45. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  46. Shirakawa K, et al. 2017. PLoS One. 12:e0186303. PubMed
  47. Zhou LJ et al. 2019. Cell Rep. 27(13):3844-3859 . PubMed
  48. Tang B, et al. 2019. Oncolytic Virother. 8:03. PubMed
  49. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  50. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  51. Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed
  52. Leyva-Castillo JM, et al. 2020. Clin Immunol. 218:108511. PubMed
  53. Bachran C, et al. 2017. Sci Rep.. 10.1038/s41598-017-17948-0. PubMed
  54. Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed
  55. Peng J, et al. 2019. Mol Brain. 12:71. PubMed
  56. Ajona D, et al. 2017. Cancer Discov. 0.773611111. PubMed
  57. Goel S, et al. 2017. Nature. 548:471. PubMed
  58. Chen L, et al. 2019. Nat Commun. 3.553472222. PubMed
  59. Dertschnig S, et al. 2020. J Clin Invest. 130:1896. PubMed
  60. Dienz O, et al. 2020. J Immunol. 204:1521. PubMed
  61. Nguyen N, et al. 2022. iScience. 25:103679. PubMed
  62. Karhadkar TR, et al. 2021. J Pharmacol Exp Ther. 376:106. PubMed
  63. Rogic A, et al. 2021. Nat Commun. 12:6889. PubMed
  64. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  65. Lechner AJ et al. 2017. Cell stem cell. 21(1):120-134 . PubMed
  66. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  67. Liu T, et al. 2020. Sci Adv. 6:eaay1497. PubMed
  68. Bredehöft J, et al. 2022. J Inflamm Res. 15:509. PubMed
  69. Tian D, et al. 2020. FASEB J. 34:3367. PubMed
  70. Stefanescu C, et al. 2021. Front Oncol. 11:765151. PubMed
  71. Dave K et al. 2017. eLife. 6 pii: e23382. PubMed
  72. Arimura K, et al. 2017. Mucosal Immunol. 1.08125. PubMed
  73. Tal MC, et al. 2020. MBio. 11:00. PubMed
  74. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  75. Lee JH, et al. 2022. iScience. 25:104166. PubMed
  76. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  77. Haney MS, et al. 2018. Nat Genet. 50:1716. PubMed
  78. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  79. Rissiek B, et al. 2017. Sci Rep. . 10.1038/s41598-017-16613-w. PubMed
  80. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  81. Si Y, et al. 2020. Sci Adv. 6:eaaw7713. PubMed
  82. Chen S, et al. 2018. Immunohorizons. 0.345138889. PubMed
  83. Yang C, et al. 2019. MBio. 10:e00595-19. PubMed
  84. Silvestre-Roig C, et al. 2019. Nature. 569:236. PubMed
  85. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  86. Guiducci E, et al. 2018. Front Immunol. 1.467361111. PubMed
  87. Guo Y, et al. 2008. Blood. 112:480. PubMed
  88. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  89. Matsuhira T, et al. 2021. Biochem Biophys Rep. 28:101118. PubMed
  90. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  91. Yan J, et al. 2020. Cancer Immunol Res. 8:356. PubMed
  92. Gomi M, et al. 2021. Mol Ther. 29:225. PubMed
  93. Chen L, et al. 2020. Front Immunol. 11:584458. PubMed
  94. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  95. Karhadkar TR, et al. 2021. PLoS One. 16:e0245924. PubMed
  96. Seelige R, et al. 2018. Sci Rep. 8:13670. PubMed
  97. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  98. Sun Y, et al. 2022. Nat Commun. 13:3916. PubMed
  99. Zhao L, et al. 2018. Nat Med. 24:1536. PubMed
  100. Manni M, et al. 2018. Nat Immunol. 1.074305556. PubMed
  101. Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed
  102. Lai JF, et al. 2020. J Allergy Clin Immunol. 146:1406. PubMed
  103. Vukman KV, et al. 2020. J Extracell Vesicles. 10:e12023. PubMed
  104. Francis M, et al. 2017. Toxicol Sci. 155(1):182-195. PubMed
  105. Gartlan KH, et al. 2019. Blood Adv. 2.110416667. PubMed
  106. Abboud G, et al. 2018. Front Immunol. 9:1973. PubMed
  107. Napimoga M, et al. 2008. J Immunol. 180:609. PubMed
  108. Jiang L, et al. 2022. Front Immunol. 12:730438. PubMed
  109. Sato Y, et al. 2021. BMC Cancer. 21:1222. PubMed
  110. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  111. Muraleedharan A, et al. 2021. Glia. 69:697. PubMed
  112. Bednarczyk M, et al. 2021. Int J Mol Sci. 22:. PubMed
  113. Shokirova H, et al. 2021. Sci Rep. 11:8647. PubMed
  114. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  115. Zhong X, et al. 2020. Proc Natl Acad Sci U S A. 8563:117. PubMed
  116. Zareie P, et al. 2017. J Neuroinflammation. 0.630555556. PubMed
  117. Wei S, et al. 2019. Virulence. 0.588888889. PubMed
  118. Kapellos TS, et al. 2017. Mediators Inflamm. 2017:4315412. PubMed
  119. Umemoto T, et al. 2017. EMBO J. 36:2390. PubMed
  120. Kim SJ, et al. 2017. Nat Immunol. 18:1016. PubMed
  121. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  122. Hakamivala A, et al. 2020. Bioact Mater. 5:142. PubMed
  123. Wicki S, et al. 2018. Int J Mol Sci. 1.266666667. PubMed
  124. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  125. Coden ME, et al. 2020. J Immunol. 204:438. PubMed
  126. Davies CL, et al. 2019. Front Immunol. 10:1048. PubMed
  127. Paharik AE, et al. 2017. Cell Host Microbe. 22:746. PubMed
  128. Nascimento DC, et al. 2017. Nat Commun. 8:14919. PubMed
  129. Shin J, et al. 2018. Diabetes. 67:1068. PubMed
  130. Majer O, et al. 2019. Nature. 575:366. PubMed
  131. Krueger A, et al. 2022. Front Microbiol. 12:789042. PubMed
  132. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  133. Manabe T, et al. 2021. J Neurochem. 159:525. PubMed
  134. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  135. Lim CS, et al. 2020. Front Immunol. 11:1186. PubMed
  136. Yoon S, et al. 2020. Antioxidants (Basel). 10:. PubMed
  137. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  138. You X, et al. 2022. Front Genet. 12:790990. PubMed
  139. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  140. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
  141. Karhadkar TR, et al. 2020. bioRxiv. . PubMed
  142. Huang S, et al. 2020. Cell Rep. 33:108394. PubMed
  143. Daley D, et al. 2017. Nat Med. 23:556. PubMed
  144. Hsieh JY, et al. 2019. APL Bioeng. 3:016103. PubMed
  145. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  146. Yi MH, et al. 2020. Brain Behav Immun. 92:78. PubMed
  147. Yoon BH, et al. 2018. Mol Cells. 41:953. PubMed
  148. Hoffmann FM, et al. 2018. Front Immunol. 9:1046. PubMed
  149. Baumgartner C, et al. 2010. J Immunol. 184:573. PubMed
  150. Meyer-Lindemann U, et al. 2022. Front Immunol. 13:898690. PubMed
  151. Tsukui H, et al. 2020. BMC Cancer. 20:411. PubMed
  152. Li J, et al. 2021. Front Immunol. 12:710406. PubMed
  153. Madsen D, et al. 2017. Cell Rep.. 10.1016/j.celrep.2017.12.011. PubMed
  154. Fino KK, et al. 2017. Sci Rep. 5.334722222. PubMed
  155. Galbas T, et al. 2017. J Immunol. 198(2):852-861. PubMed
  156. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  157. Nguyen CH, et al. 2020. Biomedicines. 8:. PubMed
  158. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  159. Speir M, et al. 2020. Nat Immunol. 21:54. PubMed
  160. Kikuchi A, et al. 2020. Am J Pathol. 190:2080. PubMed
  161. Freeman SA, et al. 2020. Science. 367:301. PubMed
  162. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
  163. Wang Y, et al. 2019. Biomed Res Int. 2019:5756189. PubMed
  164. Roussey JA, et al. 2017. J Immunol. 199:3535. PubMed
  165. Elgazar-Carmon V, et al. 2008. J Lipid Res. 49:1849. PubMed
  166. Ding L, et al. 2022. Nanoscale. . PubMed
  167. Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed
  168. Vahsen BF, et al. 2022. Sci Rep. 12:12606. PubMed
  169. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  170. Akiel M, et al. 2017. Cancer Res. 77:4014. PubMed
  171. Düking T, et al. 2022. Sci Adv. 8:eabo7639. PubMed
  172. Feng L, et al. 2019. Glia. 67:1434. PubMed
  173. Wagner AK, et al. 2017. Nat Commun. 8:15627. PubMed
  174. Wu W, et al. 2020. Brain Behav Immun. 89:245. PubMed
  175. Qiu Z, et al. 2022. Cancer Discov. 12:502. PubMed
  176. Link CWM, et al. 2020. Front Immunol. 11:596772. PubMed
  177. Lin Z, et al. 2021. Stem Cells. 39:240. PubMed
  178. Takeuchi Y, et al. 2021. Sci Rep. 11:18679. PubMed
  179. Yamasaki T, et al. 2018. J Virol. 92:e01458. PubMed
  180. Nicolas-Boluda A, et al. 2021. eLife. 10:00. PubMed
  181. Lee YJ, et al. 2018. Front Microbiol. 9:83. PubMed
  182. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  183. Cané S, et al. 2021. J Immunother Cancer. 9:. PubMed
  184. Udumula MP, et al. 2021. Mol Metab. 53:101272. PubMed
  185. Murenu E, et al. 2021. Mol Ther Methods Clin Dev. 20:587. PubMed
  186. Murenu E, et al. 2021. Int J Mol Sci. 22:. PubMed
  187. Karuppuchamy T, et al. 2020. Inflamm Bowel Dis. 216:26. PubMed
  188. Aikawa S, et al. 2020. Cell Death Differ. 1489:27. PubMed
  189. Heib T, et al. 2021. Cell Reports. 35(6):109102. PubMed
  190. Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
  191. Rossnagl S, et al. 2016. PLoS Biol. 14: 1002562. PubMed
  192. Sun Y, et al. 2015. Proc Natl Acad Sci U S A. 112: 10401-10406. PubMed
  193. Olver S, et al. 2005. Cancer Res. 66:571. PubMed
  194. Cole C, et al. 2018. Nucleic Acids Res. 46:e62. PubMed
  195. Andrews AR, et al. 2019. Cancer Cell Int. 0.955555556. PubMed
  196. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  197. Wen J, et al. 2021. PLoS Pathog. 17:e1009738. PubMed
  198. Diao J, et al. 2018. J Immunol. 201:1306. PubMed
  199. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  200. Ortiz A, et al. 2019. Cancer Cell. 35:33:00. PubMed
  201. Winter C, et al. 2018. Cell Metab. 28:175. PubMed
  202. Hsieh YL, et al. 2019. Cell Reports. 29(8):2134-2143.e7. PubMed
  203. Zheng C, et al. 2021. J Extracell Vesicles. 10:e12109. PubMed
  204. Larson–Casey JL, et al. 2019. J Clin Invest. 129:4962. PubMed
  205. Zhang J, et al. 2019. Onco Targets Ther. 12:4985. PubMed
  206. Song M, et al. 2020. Nat Commun. 11:6298. PubMed
  207. Dubik M, et al. 2021. Front Neurosci. 15:682451. PubMed
  208. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  209. Chevrier S, et al. 2018. Cell Syst. 0.675. PubMed
  210. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  211. Li X, et al. 2020. J Clin Invest. 130:4182. PubMed
  212. Kang SH, et al. 2018. Oncoimmunology. 8:e1515057. PubMed
  213. Shao Y, et al. 2017. Onco Targets Ther. 10:2675. PubMed
  214. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
  215. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  216. Flores I, et al. 2021. Hum Mol Genet. Online ahead of print. PubMed
  217. Li Y, et al. 2021. Life Sci Alliance. 4:. PubMed
  218. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
  219. Ito Y, et al. 2018. J Exp Med. 215:2617. PubMed
  220. Regan–Komito D, et al. 2017. Front Immunol. 1.459027778. PubMed
  221. He X, et al. 2017. Cancer Biol Ther. 0.815277778. PubMed
  222. Torika N, et al. 2018. CNS Neurosci Ther. 24:231. PubMed
  223. Zhou N et al. 2018. Protein & cell. 10(2):87-103 . PubMed
RRID
AB_312784 (BioLegend Cat. No. 101201)
AB_312785 (BioLegend Cat. No. 101202)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD11b
Specificity Alt (DOES NOT SHOW ON TDS):
CD11b
App Abbreviation (DOES NOT SHOW ON TDS):
FC,CyTOF®,IP,IHC-F,ICC
Hidden Names (DOES NOT SHOW ON TDS):
aM integrin, alpha integrin, alphaM integrin, alpha M integrin, integrin alphaM, integrin aM, integrin alpha M, CD11, Macrophage, Myeloid Dendritic Cell, Neutrophil, NK Cell, Plasmacytoid Dendritic Cell, Microglia
UniProt
View information about CD11b on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Spark PLUS B550™ anti-mouse/human CD11b M1/70 FC
Go To Top Version: 4    Revision Date: 12.13.2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account